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Results for "

xeroderma pigmentosum

" in MedChemExpress (MCE) Product Catalog:
Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-111648
    6-O-Methyl Guanosine

    		Nucleoside Antimetabolite/Analog Inflammation/Immunology
    6-O-Methyl Guanosine is a modified nucleoside . 6-O-Methyl Guanosine (6-methylguanosine) inhibit colony-forming ability in a malignant xeroderma pigmentosum cell line .
    6-O-Methyl Guanosine
  • HY-139038
    TDRL-X80

    		DNA/RNA Synthesis Cancer
    TDRL-X80 is a potent inhibitor of xeroderma pigmentosum group A (XPA) protein. TDRL-X80 inhibits XPA’s DNA binding activity. TDRL-X80 exhibits activity against single, double, and Cisplatin-damaged DNA with IC50s of 18, 20, and 29 μM in fluorescence polarization (FP) analyses , and with IC50s of 21, 39, and 28 in ELISA Analysis .
    TDRL-X80
  • HY-153791
    FEN1-IN-6

    		FLAP Cancer
    FEN1-IN-6 (compound 9) is a potent inhibitor of Flap endonuclease-1 (FEN1, IC50=10 nM), involving in mammalian cells to repair DNA damage. FEN1-IN-6 also targets to related endonuclease, xeroderma pigmentosum G (XPG) with an IC50 value of 23 nM .
    FEN1-IN-6
  • HY-153792
    FEN1-IN-7

    		FLAP Cancer
    FEN1-IN-7 (compound 16) is a selective inhibitor of Flap endonuclease-1 (FEN1, IC50=18 nM), involving in mammalian cells to repair DNA damage. FEN1-IN-7 also targets to related endonuclease, xeroderma pigmentosum G (XPG) with an IC50 value of 3.04 μM. FEN1-IN-7 increases the cellular sensitivity of cancer cells to potent DNA alkylating agents or methylating agents .
    FEN1-IN-7

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